In April 1810, the medical school graduated its first class of five students. They were believed to be listed among the names of those licensed to practice by the faculty. The names included Francis Cooksey, George T. Gunby, James Orrick, William H. Dorsey, and either Robert Armstrong or Handy Harris Irving.

In 1900, John C. Hemmeter, class of 1884, published Diseases of the Stomach. As professor of physiology at Maryland, he limited his practice to diseases of the stomach and intestines, and his research and writings on the subject earned him an international reputation. He originated an instrumental method of investigating the duodenum by intubation in the human patient, and was the first to visualize and diagnose a gastric ulcer with the X-ray by means of an opaque meal.

In 1975, Maurice M. Reeder, class of 1958, co-authored Gamuts in Radiology, the first reliable text dealing with differential diagnosis. He was chairman of the department of radiology at the University of Hawaii from 1978 to 1997.